THE NEW IMPERATIVE FOR REGENERATIVE MEDICINE
DUEL TECHNOLOGIES FOR CLINICAL THERAPEUTICS
It matters little how evolutionarily complex human bodies appear, they are still held together at the Quantum Mechanical Realm; this is the reality wherein MANIFESTED MATTER was created 380,000 years after THE BIG BANG.
To date, world-wide research done under the heading of medical research in the main involves chemistry, biology, physiology, microbiology, DNA, cells molecules etc.,etc. These studies are usually done in a fragmented manner within the realm each of these specialties. The countless published peer reviewed, well researched papers have added greatly to the knowledge of each specialized subject. However, this well documented information even when combined with each specialty mentioned above has not contributed to radical improvement in countless clinical pathologies that persist in human beings.
What is missing? Could the missing ingredients represent the actual basis of our Universe?
Our Universe contains only 4.9% of “MANIFESTED MATTER”(M-M). That comprises absolutely everything that we can see, touch and measure, which includes galaxies, stars, planets, clouds, and all the stuff on planet Earth. After the Big Bang of our Universe ignited, this small amount (4.9%) became hydrogen clouds that eventually evolved into galaxies, stars, etc., including us. What is holding all of the M-M, galaxies , stars, us, together?
We are herein obliged to review what the composition of matter actually is, and then to further extrapolate whether its finite structures are relevant in human pathological processes?
THE QUANTUM REALM
There is a disturbing reality that all of M-M, that is the 4.9%, is all held together by the Electromagnetic and the Strong Forces. That includes the galaxies, the stars, and each and every element that comprises human cells, molecules, and every atom in human bodies. (See the blog on the website ”When Did Our Actual Universe Start”)
The question to date, which has never been addressed, “ Is the “Quantum Realm” affected in the pathology of human tissues? Since all atoms in human bodies are held intact by the aforementioned Forces, does pathological processes disrupt alignment of the the elements therein, which may include disturbed compromises in the molecules, the cells, the tissues, the organs, and the individual? Further, in a pathological condition, what is happening to the entangled electrons that are the major binding particles of each and every compounded molecule that holds every thing together in a human body? Are the entangled electrons compromised?
A SUCCESSFUL THERAPY MAY FOREVER REMAIN A MYSTERY
Though the Quantum Realm is an enigmatic challenge, there has been a
breakthrough in clinical therapies. The usage of Electron and Electromagnetic technologies have had successful results for a growing number of diverse clinical conditions. The major technology in this field is referred to as PULSED ELECTROMAGNETIC FIELDS (PEMFs) There are ongoing clinical trials, that are FDA approved. There are also non-approved, available PEMFs devices that are used by medical practitioners throughout the world. A partial list of these clinical applications are as follows:
Non-healing bone fractures
Obsessive compulsive behavior
Various aspects of cancer
Conservative medical practitioners deem these positive results as “SNAKE OIL”. Nonetheless, there is an active market worldwide for the PEMFs devises that medical practitioners and private individuals have purchased. Worldwide results of the medical practitioners that use this technology for a myriad of clinical problems in their patients attest to their consistent successful results. Further, the testimonials by the majority of private individual’s usages of the PEMFs are very positive. It is definitely not a placebo effect as seen by many double-blinded clinical trials.
THE INITIAL TIMELINE FOR ITS SUCCESS IS KNOWN
The establishment herein is that the initiation of MANIFESTED-MATTER was accomplished by the ELECTROMAGNETIC and STRONG FORCES some 380,000 years after the BIG BANG. There is further clinical evidence that the application of ELECTROMAGNETIC THERAPIES have had a positive effect for diverse pathologies. Perhaps these positive therapeutic effects are helping correct manifested discrepancies created by pathologies within the enigmatic QUANTUM REALM. A reasonable question arrises of why this therapy can positively affect so many diverse cells and tissues? Whereas modern medicine has strode to package each diagnostically named clinical condition, and to treat these differently named pathologies with specific pharmaceutical regimens, why and how does E-M THERAPIES positively effect so many different cells, tissues and neurological conditions? If these E-M THERAPIES are affecting the QUANTUM REALM, the question becomes mute as that realm is at this “space-time” unknowable. Nonetheless, this valuable therapeutic technologies work exceedingly well so why question its continuous success. The question now becomes “How can this therapeutic success be enhanced?
CLICK BELOW FOR CONFORMATION REFERENCES
Supported by 95 peer-review references
PATHOLOGICAL PROCESSES POSE MANY MORE CLINICAL PROBLEMS THAN PEMFS CAN COMPLETELY REVERSE. CHRONIC CONDITIONS IN CELLS, TISSUES, AND ORGANS NEED INDUCED CORRECTIONS FOR REVERSALS TOWARD MORE YOUTHFUL HEALING EFFECTS. LOCALLY APPLIED FETAL MOLECULES HAVE BEEN SHOWN TO INDUCE THIS TYPE OF REVERSAL WETHER THEIR PRODUCED ACTIVITY IS ELECTRICAL, PHYSIOLOGICAL OR CHEMICAL.THEREFORE, THE PROPOSED CLINICAL APPLICATION OF FETAL MOLECULES FOLLOWS.
THE OTHER HALF OF THE DUEL THERAPEUTIC APPLICATION
Considering that the E-M is the most primitive aspect of MATTER, perhaps the most evolved manifestation of MATTER could be the missing link for a total enhancing clinical therapeutic effect. In humans, the most evolved ingredients are its molecules, cells, tissues, organs and the individual. The reality is that it is the normal human molecules that are DNA programmed ingredients that maintain each and every minute aspect of all of those individual’s “parts”. That includes all of the more than 75 trillion cells etc. The tremendously diverse molecules are the work-horses of each cell and are the highly evolved keys for the vital maintenance of the total individual.
The billions of dollars spent on research of Stem Cells, Biotechnology, Nanotechnology and the like have not to date produced the promise of their intended solutions for therapeutic clinical applications. The chemistry of modern pharmaceuticals have caused so many dire side effects, that their advertising on TV seems be a joke when admitting to those sometimes life threatening side effects. Nonetheless, there could be an answer.
THE MOLECULES FOR REGENERATIVE MEDICINE
The promise of Regenerative Medicine has still not been fulfilled. The only therapies that approach this ideal are Apligraph and Dermagraft, both owned by Organogenesis, distributed worldwide by the prominent pharmaceutical giant Novartis. The therapies for both of these products, are with some minor differences, involve placing normal cells (foreskin fibroblasts) onto non-healing chronic wounds. These therapies have been quite successful, however, just how these treatments work are a mystery to the manufacturer. Neither of these therapies cells become incorporated into the wound itself. Although FDA approved, the company offers no explanation for their efficacious results. There have been a few research papers relating to these products, have shown that fibronectins and growth factors do become incorporated into wound sites. These healing molecules without a doubt are coming from the live foreskin fibroblasts that are in close association with the chronic wounds. Nonetheless, the company does not claim these facts into their literature.
There a logistical problem with both of these therapies. The practitioner is obliged to call the company to obtain the therapeutic units as fresh as possible to coincide with the patient’s appointment. There is a critical timeline wherein these products need to used, or the live cells will deteriorate. Further, a vast population of individuals with chronic wounds reside in nursing home types of facilities. These facilities may not be able to coordinate using live cell therapeutics. Therefore, the needs of these individuals are not as of this time met. However, there is an answer to meet this dilemma for this specific therapy.
THE SOURCE OF MOLECULES FOR REGENERATIVE MEDICINE
PLACENTAS FOR OBTAINING DIVERSE THERAPEUTIC AGENTS
Human Placentas have been researched for many decades world-wide. Recently there have been proposals to utilize their tissues which contain a myriad of biological molecules, as therapeutic agents, that may have
tremendous potential for clinical applications for many pathological conditions. (1) Further, a prominent type of cell of placental tissues, trophoblasts, contain factors that confer viral resistance from maternal blood to the growing fetus.(2) Though most of the research with placental tissues are focusing on using these fetal-type cells as implantable stem cells, a more practical use of the cells therein should prove to have superior clinical applications. The clinical usage of placental tissues in any manner overcomes the world-wide controversy of the use the embryonic stem cells. Placental tissues, which are fetal tissues, are readily available everywhere on planet Earth. In the past they have been discarded. Furthermore, resent research has shown the even frozen placental tissue retains its biological activity. Using these tissues with microbiological technologies will produce therapeutic molecules that could potentially enhance many clinical applications. These molecules are the same products that our bodies produce for our total health maintenance. The usage of these natural human molecules as therapeutic agents should eliminate the side effects of implanting live stem cells that are not autologous.
THERE ARE MICROBIOLOGICAL PROTOCOLS THAT CAN PURIFY THESE MOLECULES, STERILIZE THEM AND FREEZE DRY THEM.
THEY CAN FURTHER BE STORED FOR 2 YEARS WITHOUT LOSING THEIR BIOLOGICAL ACTIVITY. IN A CLINICAL SETTING THESE MOLECULES CAN BE RECONSTITUTED AND THERAPEUTICALLY APPLIED
THERAPEUTIC MOLECULES CONTAINED IN PLACENTAS
Placenta’s villainous tissues are composed three layers of components with different cell types in each. 1-Trophoblasts (2 types, one a stem cell type) that form the interface between the fetus and the maternal environment. 2-Mesenchymal cells and Fibroblasts. 3- Fetal vascular cells. The various cell types of each component layers have been continuously researched for decades. (3) The remarkable orchestration of the placental’s role of initiating and producing a total term human baby remains enigmatic.
Nonetheless, the molecules that contribute to this accomplishment in many cases have been identified, such as a myriad of growth factors. (3) In 1984 Cellular Fibronectin was isolated and characterized from placental tissues. (4)
The purification of the structural molecules and growth factors within placental tissues should contribute many clinical applications for the enhancement of Regenerative Medicine.
LARGE SCALE TISSUE CUTURE FOR PLACENTAL CELLS
There is carefully researched evidence the that full term fetal type placental cells could be propagated for over 100 doublings. Further, telomere activity had been monitored for these long term culture and it was found that these cells did not show any signs of aging. (1) Therefore, large scale cell culture of these fetal placental cells could be expanded exponentially so that molecular production and manufacture could complete with Biotech technologies.
The concepts proposed in this paper will solve the following problems facing Biotech companies and Stem cell clinical endeavors:
– Elimination of the philosophical problem of embryonic stem cell usage.
- Elimination of the immunological factors in stem cell transplants.
- Biotech technologies usually cannot produce exacting total natural molecules.
CONCLUSIONS FOR PLACENTAS
Regenerative Medicine has not as yet been consistently nor totally attained. There is a naivety in the use of stem cells therapeutically. It is the MOLECULES that cells produce that are the therapeutic agents. If stem cells are regionally transplanted and are not adaptable to that particular area, they would not produce the specific molecular therapeutic agents for healing that particular pathology. Biotech technologies have not produced exacting molecules the human bodies recognize as self without side effects. The proposals herein could eliminate these clinical conundrums.
- Multiplipotent Stromal Stem Cells from Human Placental Demonstrate HighTherapeutic Potential.Igor Nazarov, et al. Stem Cells Trans Med 2012 1:359-372.
- Autophagy as a mechanism of antiviral defense at the maternal?fetal interface. Delorme-Axford E, et al. Autophagy 2013 Dec 1; 9(12): 2173-2174
- Chapter 4 Cell Types of the Placenta. Wang Y, and Zhao S. Vascular Biology of the Placenta. Bookshelf ID NBK 53245.
- Isolation and characterization of human placenta fibronectin. Isomer M. et al. J MANY 1984 Jul; 96(1) 163-9.
A NEW ERA THAT WILL FOREVER CHANGE MEDICAL THERAPEUTICS AND PROVIDE THE TECHNOLOGIES TO FULFILL THE PROMISE OF REGENERATIVE MEDICINE HAS BEEN CONCEPTUALIZED IN THIS PRESENTATION. WHILE NOT SUGGESTING SPECIFIC APPLICATIONS OF THE HEREIN DESCRIBED THERAPEUTIC TECHNOLOGIES FOR SPECIFIC PATHOLOGICAL CONDITIONS, IT SHALL BECOME THE DOMAINE OF THE HEALTH SPECIALIST AS TO HOW, WHEN AND WHERE TO CLINICALLY PROVIDE THE CORRECT APPLICATION OF SAME.