THE PREMISE OF UTILIZING NORMAL MOLECULES AS THERAPEUTIC AGENTS
The conceptual idea of using normal human molecules as therapeutic agents is obliged to be reviewed as an evolutionary premise. The Big Bang Theory is that our Universe came into existence from a small singularity and exploded violently outward containing all of the energies and forces of energies that eventually evolved into our present day Universe. The well known concept of “Entropy” states unequivocally that in our Universe that the more simple will evolve into the more complex (1) (2).Research in all separated fields of science has confirmed this concept as an “Absolute”; it is seen in particle physics and through all of the phases of evolved biological structures. However, there is a problem in the interpreting of the complexity of present day structures. That problem is that at the tiniest levels of all structures exist in the enigmatic realm of the quantum world. This truism is often over looked in the research for obtaining therapeutic agents for human diseases and problematic conditions. The quest herein is to address this enigma and to point the way for solutions that heretofore were not considered for obtaining human therapeutic agents.
Expanding the ideas expressed in the paragraph above, we shall proceed to the nucleus of present day human differentiated cells wherein reside the highly evolved genes. By-passing human embryonic growth into human differentiated organs and all other tissues that make up a total human being, we note the following.
The genes of each and every differentiated cell type has their own specific “Agendas”. Not reviewing these specific complexities therein, the agendas in simple terms are to produce all of the proteins and related molecules in order to keep that particular cell phenotype normal and healthy. The dynamics of their particular cell anatomies can be seen under a microscope, however the millions of chemical, biochemical, and physiological reactions that are occurring second to second are impossible to interpret. And, is less possible to comprehend at their quantum levels. Nonetheless, there may be a solution.
In terms of biological evaluation, the genes are relatively simple structures, however, the molecules that they produce are thousands of times more complex. A great portion of those molecules reside at the periphery of cells as a highly dynamic complex entity known as the Extracellular Matrix (ECM). The ECM is specific for each cell type and is a highly cooperative entity that consists, depending, on the cell type, as dozens to over a hundred different molecules. All of the totalities of the functions of these different ECMs have not been elucidated, however, there are clues to some their important functional abilities. It has been recognized that there a communication from these ECMs to the genetic nuclear machinery. Put simply, the specific ECMs are dynamic actions zones that that functions to instruct cellular phenotype (3). This mechanism induce genetic production for a myriad activities such as remodeling of injured or impaired diseased molecules and further to renew its differentiated phenotype. The genes in their protected, secluded domains within their nucleus envelope need the ECM’s informational communication for its survival. Now we proceed to the rationale of finding normal human therapeutic agents.
The premise herein is simple. If ECM molecules dictate to the genes to produce their programmed agendas, and inform the genes when disease states occur on/or in those particular cells, utilizing ECM molecules as therapeutic agents at the least makes biological sense, as it has been determined that the ECMs give genes information from the outside-in. These exogenously placed molecules will be able to take over when the original ECMs become impaired for any reason. THIS WEBSITE SHOWS THE TECHNOLOGIES THAT CAN PRODUCE THOSE MOLECULES.
- To be at the right place at the right time. Kayser K., Diagnostic Pathology 2011 6:68
- Thermodynamic of cosmological matter creation. Prigogine I., Proc Natl Acad Sci USA 1988 Oct; 85 (20): 7428-32
- Extracellular Matrix remodeling and Cellular Differentiation. Streuli C., Curr Opin Cell Boil. 1999 Oct; 11 (5): 634-40